Retrospective Clinical Evaluation of Platelet-Rich Plasma Application in Oral Surgery in Adults

Platelet-rich plasma (PRP), an autologous blood concentrate rich in platelets and growth factors, has gained popularity in oral surgery due to its potential to enhance healing and reduce post-operative complications. However, its efficacy remains debated due to variations in preparation and application protocols. This retrospective comparative clinical study aimed to evaluate the healing enhancement and safety of PRP in various oral surgical procedures, such as tooth extractions, sinus lifts, periapical surgeries, and cyst enucleations, compared to a control group treated without PRP. A total of 84 adult patients (mean age 42.9 years) were included: 42 received PRP (study group) and 42 underwent standard surgery without PRP (control group). Healing was evaluated clinically and radiographically based on soft tissue closure, post-operative pain (Visual Analog Scale), infection, and bone regeneration. By day 30, complete soft tissue healing was achieved in 94.1% of PRP-treated cases versus 76.4% in controls (P < 0.05). Mean pain score on day 10 was 2.1 in PRP versus 3.8 in control (P < 0.01). Radiographic bone density increased in 6 months by 28.5% in PRP-treated sites and 14.2% in controls (P < 0.01). Patient satisfaction was higher in the PRP group (8.4 vs. 7.1). PRP appears to significantly improve both soft tissue and bone healing in oral surgical procedures compared with standard care, with high patient satisfaction and a favorable safety profile. Further prospective controlled trials are recommended for standardized protocol validation.