The effect of procoagulant platelets on coagulation and fibrinolysis

Activated platelets are divided into two subpopulations: proaggregatory and procoagulant. The procoagulant subpopulation of platelets began to be actively studied about 20 years ago. This type of platelets has a large number of procoagulant proteins on its surface. It is already known what mechanisms are responsible for the distribution of platelets into subpopulations and how this process can be influenced. At the moment, this knowledge is not used in medical practice. There are reports in the literature on the relationship between the number of procoagulant platelets and some pathological conditions of the body, such as heart attacks, strokes, etc. However, accurate information on the contribution of procoagulant platelets to the physiology of thrombus formation is insufficient. This review collects known literary data on the interaction of the procoagulant subpopulation of platelets with the blood coagulation and fibrinolysis systems. The literature analysis showed that the relationship of the procoagulant subpopulation with fibrinolysis has not been sufficiently studied. Procoagulant platelets have both lysis-promoting and lysis-protecting proteins. The quantitative contribution of this subpopulation to fibrinolysis is unknown. Thus, further study of the physiology of procoagulant platelets is necessary to develop new therapeutic approaches using the properties of this subpopulation.