Single-cell thiol profiling enabled by live-cell labeling reveals metabolic heterogeneity in ferroptosis
Abstract
The untargeted single-cell metabolome library was established based on UPLC-MS/MS identification at population level and algorithmic recognition at the single-cell level. The single-cell metabolome information could be extracted by a four-step workflow based on algorithm: format transformation, EIC extraction, single-cell event authentication and normalization.
Fields of Study & Subjects
Metabolomics and Mass Spectrometry Studies
Ferroptosis and cancer prognosis
Single-cell and spatial transcriptomics
Publication details
- Journal / source
- Code Ocean
- Publication date
- 1 January 2026
- Language
- EN