Benzimidazolinone synthesis through hypervalent iodine-mediated cycloaddition between aryl isocyanates and O-substituted hydroxylamines
Abstract
We developed a one-pot cycloaddition methodology for the synthesis of benzimidazolinones, which involves the formation of arylureas using O-benzyl hydroxylamine as a specific nitrogen source, followed by oxidative aromatic C-H amination promoted by hypervalent iodine reagent and catalyst.Our protocol utilized readily available starting materials, thereby enabling rapid access to the target benzimidazolinones.Additionally, the product from this one-pot process was further derivatized to produce an N,N'-disubstituted benzimidazolinone.
Fields of Study & Subjects
Oxidative Organic Chemistry Reactions
Synthesis and Reactions of Organic Compounds
Organic Chemistry Synthesis Methods
Publication details
- Journal / source
- ARKIVOC
- Volume
- 2025
- Issue
- 4
- Publication date
- 16 February 2026
- Language
- EN