Somatic-type malignancy transformation in testicular germ cell tumors

Background: Germ cell tumors (GCTs) are the most common testicular neoplasms.Although they have a good prognosis, malignant somatic transformation (MST) is an infrequent but aggressive complication.Materials and methods: An observational, longitudinal, analytical study was conducted, reviewing the medical records of male patients over 15 years old with GCT who were treated between 2024 and 2025.Results: MST was identified in a small group of cases, with localization in the testicle and retroperitoneum.The most common histologic type was embryonal neuroectodermal.Discussion: MST is resistant to targeted schemes such as BEP.The need for complete surgical resection and subtype-specific chemotherapy was highlighted.Conclusions: MST requires an aggressive multimodal treatment approach to achieve better outcomes.Strategies for detection and treatment should be improved.