Post-occlusive Reactive Hyperemia in Individuals with Arterial Hypertension According to Portable Dual-Channel Laser Blood Microcirculation Analyzer

Purpose – to conduct a comparative analysis of the parameters of post-occlusion reactive hyperemia development in apparently healthy individuals and patients with arterial hypertension, using a portable dual-channel laser blood microcirculation analyzer. Materials and methods. Two observation groups were formed: patients with arterial hypertension (AH group, n=39) and healthy individuals (control group, n=32). Microcirculation parameters were determined during the occlusion test using laser Doppler flowmetry. The fluorescence amplitude of the coenzyme – reduced nicotinamide adenine dinucleotide (NADH) – was determined using laser fluorescence spectroscopy. The content of nitrates and nitrites (NOx) in the subjects’ blood serum was determined and the deformability of erythrocytes after their incubation with the NO donor – sodium nitroprusside – was assessed. Results. The initial indicator of microvascular perfusion in the observation groups did not differ statistically significantly. In the AH group, the maximum perfusion value (MPmax) achieved during the development of reactive post-occlusive hyperemia was 20% lower (p