Development and study of nanogels and nanoparticles with anti-inflammatory drugs for local application in periodontal pockets

Aim. To analyze and systematize data on modern and promising nanotechnological methods (in particular, nanogels and nanoparticle composites) for the treatment of periodontitis with a focus on local drug delivery systems. Materials and methods. The method of systematic review and biblio-semantic analysis of scientific medical literature was used for the analysis; 78 sources of information were processed, of which 13 were selected for detailed review. The PubMed, Scopus, Web of Science, and Google Scholar databases were also used to search for information. The study object was modern nanotechnological drug delivery systems. Results. Nanoparticle-hydrogel composites (nanogels) show significant advantages over individual components, providing multi-medication therapy, high bio-adhesiveness, and controlled drug release. The high potential of chitosan as a multifunctional platform for antimicrobial and regenerative therapy has been confirmed. Conclusions. Nanogel systems are a promising platform for local drug delivery in periodontal pockets, capable of providing a targeted, controlled therapeutic effect and overcoming the problem of the short residence time of traditional dosage forms.