From Editor-in-Chief: On current issue, acknowledging the best in 2025, new guidelines and statements

diseases, surgery and internal medicine.We published original research articles on: on morphological characteristic of brain glial tumors, on relation of obesity and diabetic nephropathy, on factors determining mortality in stroke-related hematoma of supratentorial region, on risk factors of congenital heart disease development in children, and treatment of endotoxicosis associated with peritonitis.Review articles may be of interest for you as they multidisciplinary: preparation of medical staff for work in industrial zones located in extreme conditions of high altitudes, on frailty assessment and effects of national sports on development of children and adolescents and effect of oxidative stress, nitric oxide signaling hypoxia inducible factor in chronic lower limb ischemia.You can find very rare interesting case on ablation of atrioventricular tachycardia in a young men with genetically confirmed William Beuren syndrome and supravalvular aortic stenosis and case report on concealed changes in myocardium detected by strain imaging in an otherwise healthy woman with right bundle branch block.I have an honor to announce the outstanding articles and their authors published in 2025 and the most read and most downloaded