A new glutarimide compound from Streptomyces sp. JCM 4793

Records of Natural Products 2026 Open access

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Authors: Z. G. Zhao, Lin-Fang Tang, Han-Jun Guo, Yuan CHEN, Meng-Meng Hu, Yubing Hong, Rong Zhao, Mingming Cao, Jia Chen, Yanyun Che
DOI: 10.25135/rnp.2510.3694
Cited by: 0

Abstract

In this study, a previously undescribed glutarylimide compound was isolated from Streptomyces sp. JCM 4793. Its structure was evaluated through examinations of the NMR, HREIMS data and ECD calculation. Compound 1 was measured for its cytotoxicities against A549, K562, HepG2, SW480 and MDA-MB-231 cells. Compound 1 exhibited significant inhibitory activity against both K562 and A549 tumor cell lines, with IC50 values of 4.840 ± 0.329 μmol/L and 6.036 ± 0.157 μmol/L, respectively.

Fields of Study & Subjects

Microbial Natural Products and Biosynthesis Cancer therapeutics and mechanisms Synthesis and Biological Activity

Publication details

Journal / source
Records of Natural Products
Volume
20
Issue
1
Publication date
1 January 2026