GNPS molecular networking-guided discovery of antifungal butenolides from the endophytic fungus Aspergillus sp. FH-1 of Valeriana officinalis L.

Records of Natural Products 2026 Open access

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Authors: Hao Fan, Xin Wang, Yinhan Teng, Pingping Wu, Haifang Wang, Yuze Li, Henglei Niu, Wei Wang, Xiaomei Song, Qing Chang, Dongdong Zhang
DOI: 10.25135/rnp.2512.3778
Cited by: 0
References: 19

Abstract

Guided by an integrated GNPS molecular networking strategy, the chemical investigation of endophytic fungus Aspergillus sp. FH-1 (isolated from Valeriana officinalis L.) led to the discovery of four butenolides (1-4). Their structures were elucidated through comprehensive spectroscopic data analysis, including HRESIMS, 1D/2D NMR and ECD, revealing two new congeners, asperianas A (1) and B (2), along with the known analogues 3 and 4. Notably, compounds 1 and 3 exhibited significant antifungal activity against Colletotrichum gloeosporioides, with EC50 values of 19.23 ± 1.14 and 43.36 ± 1.12 μg/mL, respectively.

Fields of Study & Subjects

Microbial Natural Products and Biosynthesis Sesquiterpenes and Asteraceae Studies Bioactive Natural Diterpenoids Research

Publication details

Journal / source
Records of Natural Products
Volume
20
Issue
1
Publication date
3 March 2026
Language
EN