Formulation and Evaluation of In Situ Gel of Gentamicin Sulphate

The formulations of topical ophthalmic drugs may not be absorbed and are eliminated before producing an action due to lacrimal fluid.The novel formulation of an in-situ gel for gentamicin sulphate, the antimicrobial agent, involves adding polymers like chitosan, guar gum, and sodium alginate to enhance the bioavailability of the drug.The formulation process includes continuously mixing the polymer solution with the drug solution until a clear, viscous solution is formed, adding preservatives, stabilizing agents like PEG, and adjusting its pH with an acetate buffer solution suitable for ocular use.The product was sterilized using a 0.2 μm filter membrane.An in-situ gel was prepared and treated with STF to confer gelling properties.These gelling properties are due to the polymers involved in the formulation, which promote the drug's bioavailability and retention time in the eye.The formulation was evaluated as suitable for ophthalmic use conditions.