Disguised discoloration: Minocycline-induced pigmented cardiac valves
Abstract
Tetracyclines are used for a variety of dermatologic conditions, and a known side effect of this therapy is hyperpigmentation in multiple tissues throughout the body. We present the case of a 66-year-old man who underwent aortic valve replacement and was found to have discoloration of the aortic valve leaflets associated with his chronic use of minocycline for rosacea. Minocycline-induced pigmentation of cardiac valves is a documented, although uncommon, phenomenon. There is no evidence linking valve pigmentation to functional valve defects. This case highlights an infrequent manifestation of minocycline-induced pigmentation.
Fields of Study & Subjects
Acne and Rosacea Treatments and Effects
Dermatologic Treatments and Research
Chemotherapy-related skin toxicity
Publication details
- Journal / source
- Dermatology Online Journal
- Volume
- 31
- Issue
- 6
- Publication date
- 5 January 2026
- Language
- EN