Triphasic Malignant and Benign Transformation within a Nevus Sebaceus: Concomitant Basal Cell Carcinoma, Squamous Cell Carcinoma, and Apocrine Adenoma

SKIN The Journal of Cutaneous Medicine 2026 Open access

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Authors: Fiona S. Gruzmark, Taha Faiz Rasul, Benjamin Cooper, Anthony Concilla, Charles Perniciaro, Juan Rosario-Collazo
DOI: 10.25251/gm31c816
Cited by: 0
References: 5

Abstract

Nevus sebaceus is a congenital hamartoma that may undergo secondary neoplastic changes, most commonly benign adnexal tumors. Malignant transformation is rare, and the simultaneous occurrence of multiple neoplastic entities is exceedingly uncommon. We report a rare case of a 49-year-old man with a nevus sebaceus of the scalp harboring basal cell carcinoma, squamous cell carcinoma, and an adjacent apocrine adenoma, representing a rare triphasic transformation.

Fields of Study & Subjects

Cancer and Skin Lesions Nonmelanoma Skin Cancer Studies Cutaneous Melanoma Detection and Management

Publication details

Journal / source
SKIN The Journal of Cutaneous Medicine
Volume
10
Issue
1
Pages
2900–2905
Publication date
13 January 2026