Comparative Effectiveness of Autologous Platelet-Rich Plasma vs. Conventional Dressings in Chronic Ulcer Management

Background: Chronic ulcers pose a major clinical challenge due to delayed healing and high recurrence rates. Autologous platelet-rich plasma (PRP) has emerged as a regenerative therapy capable of enhancing wound repair through concentrated growth factors. Objective: To compare the efficacy of autologous PRP and conventional dressing in reducing ulcer surface area and promoting healing in chronic ulcers. Methods: This prospective comparative study included 80 patients with chronic ulcers, randomized into PRP and control groups. Ulcer surface area was measured at baseline and at Days 14, 28, and 56, and percentage reduction was analyzed. Results: While baseline ulcer size was comparable, the PRP group demonstrated significantly greater reduction in ulcer surface area from Day 14 onward, with highly significant differences observed at Days 28 and 56 compared with the control group. Conclusion: Autologous PRP therapy significantly accelerates healing and reduces ulcer surface area in chronic ulcers compared with conventional dressing, supporting its role as an effective adjunctive treatment.