PAP smear cytology of Cervical lesions with Histopathological correlation

Introduction: Cervical cancer is among the leading cause of death in Indian women owing to lack of awareness and lack of a proper screening program. Objectives: To assess incidence of various cervical lesions by Pap smear in the study area and to evaluate the accuracy of Pap smear with respect to histopathology wherever possible by estimating sensitivity, specificity, predictive values so as to find the usefulness of Pap smear in screening for cervical cancer. Methodology: This was a prospective and retrospective study comprising 110 specimens subjected to Pap smears followed by Histopathological examination. Results: The most common lesion on Pap smear was atypical cells followed by positive for malignancy, SCC and HSIL. The accuracy of cytological test considering histopathological diagnosis as gold standard yielded 80% sensitivity and 92% specificity with 97.14% PPV and 57.50% NPV. Conclusion: Pap smears should be routinely advised to enable early detection of premalignant and malignant cervical lesions.