An Observational Study for the Comparison of Mineral Status (Ca, Mg & P) and Alkaline Phosphatase Levels in Middle Aged Rheumatoid Arthritis Patients with Age-Matched Healthy Individuals

Background: Rheumatoid arthritis (RA) is a progressive, systemic autoimmune disease characterized by chronic inflammation of synovial joints, systemic manifestations, and progressive joint and bone destruction. The current study was conceptualized to assess serum calcium, magnesium, phosphorus, and alkaline phosphatase levels in middle-aged patients with RA. Methodology: A total of 30 RA patients and 30 healthy controls (matched by age and sex) were recruited. After ethical clearance and informed consent, participants were subjected to clinical examination, routine blood investigations, and specific tests to estimate: Serum Calcium – Arsenazo III method, Serum Magnesium – Calmagite method, Serum Phosphorus – Ammonium molybdate method, Serum ALP – IFCC kinetic method. Results: Among all the variables studied, mineral metabolism markers (calcium, phosphorus, magnesium, ALP) and liver function abnormalities were significantly associated with RA positivity, whereas demographic and lifestyle factors were not