Cutaneous Manifestations of Chronic Kidney Disease

Background: Chronic kidney disease (CKD) is a progressive systemic disorder associated with multiple dermatological manifestations that significantly affect patients’ quality of life. Objectives: To study the spectrum and frequency of cutaneous manifestations in patients with chronic kidney disease. Materials and Methods: This hospital-based observational study was conducted from February 2023 to November 2025 at Nirmala Hospital & Research Center, Jaipur. All diagnosed CKD patients were included. Patients with acute kidney injury or pre-existing primary dermatological disorders unrelated to CKD were excluded. Detailed clinical, dermatological, and laboratory evaluations were performed. Data were analyzed using descriptive statistics. Results: A total of 327 CKD patients were studied (mean age 52.4 ± 11.6 years; male:female ratio 1.8:1). The most common etiology of CKD was obstructive uropathy (41%). Non-specific cutaneous manifestations were predominant. Pruritus (72.7%), hyperpigmentation (70%), and xerosis (67.8%) were the most frequent findings. Among specific lesions, acquired perforating dermatosis (8.5%) and porphyria cutanea tarda (3.2%) were observed. Conclusion: Cutaneous manifestations are highly prevalent in CKD patients, with non-specific lesions being more common than specific dermatoses. Early identification and appropriate dermatological care should be integrated into routine CKD management