A Prospective Randomized Single-Blind Study Comparing Cisatracurium and Rocuronium for Endotracheal Intubation in Elective Surgeries under General Anesthesia

Background: Neuromuscular blocking agents play a crucial role in facilitating optimal endotracheal intubation during general anesthesia. Rocuronium is commonly used for its rapid onset, whereas cisatracurium offers organindependent metabolism and stable hemodynamics. Comparative data on intubating conditions and physiological responses between these agents in elective non-obstetric surgeries remain limited. Objectives: To compare cisatracurium and rocuronium with respect to intubating conditions, onset of neuromuscular blockade, hemodynamic responses, and adverse effects in adult patients undergoing elective surgeries under general anesthesia. Methods: This prospective randomized single-blind study included 70 ASA I–II patients aged 20–60 years. Patients were randomized to receive either cisatracurium 0.1 mg/kg (Group C) or rocuronium 0.6 mg/kg (Group R). Intubating conditions were assessed using the Copenhagen Conference Score. Train-of-Four monitoring evaluated neuromuscular blockade, and hemodynamic parameters were recorded at predefined intervals. Results: Group C demonstrated a higher proportion of excellent intubating conditions and a faster early TOF suppression. Group R showed a higher transient pressor response post-intubation. Both groups achieved adequate neuromuscular blockade by 180 seconds, with minimal adverse effects. Conclusion: Cisatracurium provided superior intubating conditions and better hemodynamic stability compared with rocuronium in elective surgeries.