Study of Clinical Isolates of Methicillin Resistant Staphylococcus Aureus (MRSA) and its Antibiotic Susceptibility Pattern in Tertiary Care Teaching Hospital

Introduction: Methicillin-resistant Staphylococcus aureus (MRSA) is a resistant organismthat heavily contributes to hospital and community-acquired infections worldwide. It spreads very easily from patient to patient, by the hands of health workers, through contaminated objects and by air. MRSA poses a major clinical problem in treatment. So, it is essential to know its antibiotic pattern. Material & Methods: This study was carried out in the department of Microbiology at C. U. Shah Medical College and hospital, Surendranagar. Total 180 samples were included in the study during the period of 1st July 2021 to 30th June 2022. Identification of isolated organism was done by conventional method using biochemical reactions. Antimicrobial susceptibility testing and MRSA detection was done using VITEK-2 compact system. Results: Methicillin resistant Staphylococcus aureus (MRSA) was seen in 58% of the isolates. The sensitivity profile shows Tigecycline 100%, Nitrofurantoin, Linezolid and Teicoplanin 99%, Vancomycin 95%. Lower sensitivity rates were found for Levofloxacin (7%), Ciprofloxacin and Oxacillin (6%) and cefepime (2%). Inducible clindamycin resistance was found to be 37.5%. Vancomycin sensitivity was 95%, rest 4% was VISA and 1% was VRSA. Discussion: Prevalence of MRSA was found 57.78% from various clinical samples.A similar study done by Fatemeh et al and Kirti et alwas reported MRSA prevalence of 63.20% and 33.7% respectively. Conclusion: MRSA were most sensitive to Tigecycline, Linezolid, Tecoplanin , Vancomycin and least sensitive to Oxacillin and cefepime. The knowledge of antibiotic sensitivity pattern of S. aureus will therefore be helpful to get control over the evolving resistance.