Fibirogen to Albumin Ratio Severity of Coronary Artery Disease in Diabetes Mellitus Patient

Introduction: Coronary artery disease (CAD) is one of the commonest causes of mortality and morbidity. The Fibrinogen/Albumin Ratio (FAR) is a newer marker of inflammation that has been shown to be a predictor of short-term prognosis in patients with acute myocardial infarction. Utility of FAR in predicting angiographic severity of CAD and clinical outcomes is not yet clear in Indian patients. Objective: To study the role of fibrinogen-to-albumin ratio (FAR) as predictor of the angiographic severity of the coronary artery disease, and the short-term prognosis in the patients undergoing coronary angiography. Material and Methods: The present study was conducted in the Dept. of Cardiology, Sri Jayadeva Institution of Cardiovascular Sciences. A detailed history, physical examination and all routine investigations along with serum albumin, fibrinogen, ECG & 2-D Echo were done for all the patients. Samples were drawn at admission, before angiography. All the patients underwent clinically indicated invasive coronary angiography. SYNTAX SCORE was calculated using an online SYNTAX SCORE calculator. Results: Out of the 237 patients for final analysis, the majority (81.4%) were male. The mean age of the patients was 57 years. The mean fibrinogen level was 397.97 mg/dl, the mean serum albumin level was 4.05 g/dl and the mean FAR was 101.07 mg/g. with FAR below it was considered as low FAR and above it was considered as high FAR. The mean CAG Syntax score was 22.02. Majority of patients (58.6%) had acute coronary syndrome (ACS), while remaining had stable coronary artery disease. Two FAR groups were found to have comparable proportions of patients across the two Syntax score groups (low SS < 23, high SS > 23). The p-value for the correlation between FAR and Syntax Score was not significant (p=0.941). Conclusion: FAR was not found to be associated with CAD severity among Indian patients with stable CAD and ACS in the present study. This study didn’t find any correlation between the FAR and short-term prognosis.