A Study of Correlation between Histopathological and Radiological Diagnosis of Bone Tumours

Background: Bone tumors and tumor-like lesions present diagnostic challenges due to their rarity, heterogeneous presentation, and overlapping radiological features, necessitating integrated histopathological confirmation for accurate management. Discrepancies often arise in non-specialized centers from limited exposure, underscoring the need to quantify agreement between provisional radiological diagnoses and definitive histopathology using metrics like Cohen's kappa. This study addresses these gaps in a tertiary care setting in Jodhpur, India. Methods: A prospective observational study analyzed 81 bone lesion specimens (biopsies, curettage, excisions) from Jan 2023 to April 2024 at Dr. SN Medical College Pathology Department, including all ages/sexes with complete radiological data but excluding hematological malignancies or inadequate samples. Tissues underwent formalin fixation, nitric acid decalcification, paraffin embedding, H&E staining, and selective IHC; lesions were classified per WHO criteria. Cohen's kappa assessed diagnostic agreement, with p