First-trimester two-hour post-challenge glucose and HbA1c as early predictors of gestational diabetes mellitus: A prospective cohort study
Abstract
Background and objectives Traditional gestational diabetes mellitus (GDM) screening at 24-28 wk occurs after foetal exposure to maternal hyperglycemia during critical developmental windows. Our objective was to investigate whether first-trimester glycaemic parameters within currently accepted normal ranges could predict subsequent GDM development. Methods In this prospective cohort (May 2023-December 2024), 270 women with singleton pregnancies were enrolled at 8-12 wk gestation with normal glycaemic values (FPG
Fields of Study & Subjects
Gestational Diabetes Research and Management
Pregnancy and preeclampsia studies
Pancreatic function and diabetes
Publication details
- Journal / source
- The Indian Journal of Medical Research
- Publisher
- Scientific Scholar
- Volume
- 163
- Issue
- 1
- Pages
- 49–54
- Publication date
- 28 February 2026
- Language
- EN