Solitary extramedullary plasmacytoma of the nasopharynx: A case report

Solitary extramedullary plasmacytoma (SEP) is a rare form of plasma cell neoplasm that occurs in the soft tissue without systemic involvement. We report the case of an 81-year-old female patient who presented with intermittent dysphagia and was found to have a right nasopharyngeal mass diagnosed as a plasmacytoma. Diagnostic workup included endoscopy, biopsy, imaging, and laboratory analysis, which ruled out multiple myeloma. The patient underwent definitive radiation therapy, and at evaluation 4 months later, there was no metabolic or endoscopic evidence of any disease, except for minor toxicity limited to nocturnal xerostomia. This case underscores the importance of timely diagnosis and the role of radiotherapy in treating SEP, particularly in uncommon anatomical locations.