Characteristics of isocitrate dehydrogenase-1 status in adult glioma patients: Demographic, radiological, and histopathological insights from single-center study

Objectives: The objective of this study was to determine the characteristic that associated with isocitrate dehydrogenase-1 (IDH-1) status in adult glioma patients. Materials and Methods: This analytical observational study was conducted on adult glioma patients using a retrospective design. Data were obtained from medical records of patients undergoing treatment at the tertiary general hospital, Dr. Soetomo Hospital, Indonesia, from January 2018 to January 2024. The independent variables included age, gender, tumor location, tumor size, midline shift size, contrast enhancement, and histopathology anatomical grading with IDH-1 status as the dependent variable. Results: In this study, 21 IDH-1 wild (36.8%) and 36 IDH-1 mutant glioma patients (63.2%) met the inclusion and exclusion criteria. The significant predictors of IDH-1 glioma mutation status ( P < 0.05) included contrast enhancement, glioma tumor location, and histopathology anatomical grade. Conclusion: Glioma location, contrast enhancement, and histopathological grading were significantly associated with IDH-1 status in adult glioma patients that potentially be used to predict IDH-1 status in adult glioma patient.