Resolution of progressive aphasia following resection of a left frontotemporal glioblastoma: A 6-month outcome case report

Background: Subacute progressive aphasia is often seen with dominant-hemisphere glioblastoma (GBM); however, full functional recovery postresection is not usually seen. Case Description: A 65-year-old right-handed woman with new-onset progressive expressive aphasia underwent near-total resection of a 5.4 cm left frontotemporal mass. By postoperative day 2, her aphasia was fully resolved. Pathology confirmed wildtype, O6-methylguanine-DNA methyltransferase (MGMT)-unmethylated GBM. At 6 months, she remains neurologically asymptomatic without evidence of aphasia or evidence of recurrence on magnetic resonance imaging. Conclusion: This case suggests that aphasia from tumor-related mass effect and edema can be fully reversible with timely surgical intervention. Continued surveillance and adjuvant therapy have sustained her excellent neurological outcome.