Abstracts

Introduction:The goal of treatment with cyclosporine in idiopathic steroidresistant nephrotic syndrome in children is either to achieve complete remission or partial remission, as it is the most important predictor of disease outcome. Aim and Objectives:The purpose is to assess remission pattern and renal function status from the use of cyclosporine in children with idiopathic steroid-resistant nephrotic syndrome.Methods: A descriptive cross-sectional hospital-based study, conducted at the pediatric nephrology unit in Soba University Hospital, during the period from October 2021 to February 2022, covered 80 children with idiopathic nephrotic syndrome, who failed to achieve remission despite receiving oral prednisolone 60mg/SA/day for 4 weeks, and started cyclosporine therapy for 12 months Results: The mean age of the studied children was 8.5 ± 4.6 years.The maleto-female ratio was 2.1:1.The pattern of remission of use of cyclosporine in children with SRNS was complete remission in 42 (52.5%),partial remission in 17 (21.2%),and resistance in 21 (26.3%).Regarding the safety and efficacy of cyclosporine in the treatment of patients with SRNS, the study showed that severe hypertension was reported in 6.3%, and 5% showed impaired renal function.In the majority of the children, 71 (88.7%), there were no side effects. Conclusion:In Sudanese children diagnosed with idiopathic steroidresistant nephrotic syndrome, cyclosporin is the drug of choice for induction of remission.