MODERN APPROACHES TO CLASSIFICATION OF SKIN-LIMITED VASCULITIS

Skin-limited vasculitides represent a heterogeneous group of inflammatory disorders affecting the dermal vasculature and subcutaneous adipose tissue without evidence of systemic involvement. Modern classification approaches are based on clinical, morphological and immunopathological criteria, allowing differentiation of the most common forms, including leukocytoclastic vasculitis, urticarial vasculitis, thromboangiitis obliterans and druginduced variants. Skin biopsy and direct immunofluorescence are essential diagnostic tools, while integration of clinical findings with laboratory investigations contributes to standardization of classification systems. Prognostic relevance of classification lies in identifying patients at risk of systemic progression or association with autoimmune and infectious diseases.