Supporting data for Mphil thesis "UNRAVELING GENOMIC EVOLUTIONARY DYNAMICS IN HIGH GRADE SEROUS OVARIAN CANCER USING OVIDUCTAL ORGANOID MODELS"

Data uploaded here is for the project "UNRAVELING GENOMIC EVOLUTIONARY DYNAMICS IN HIGH GRADE SEROUS OVARIAN CANCER USING OVIDUCTAL ORGANOID MODELS" . This project aims to systematically explore the evolutionary dynamics of CNAs during HGSOC’s initiation and progression, and to functionally characterize the therapeutic vulnerabilities associated with chromosome 8q amplification – one of the most frequent and clinically relevant CNAs in HGSOC. Here, HGSOC precursor lesions are modelled via TP53 knockout in a non-malignant fallopian tube epithelium cell line FT190 and patient-derived benign fallopian tube organoids. Organoid models are successfully established and are currently undergoing the planned 18-month long-term culture to recapitulate disease evolution. Longitudinal sha llow whole-genome sequencing is performed periodically to track CNA dynamics over time.