KDM6B Acts via BMP Signaling During Root Morphogenesis

FaceBase Craniofacial Research Data Repository 2026 Dataset Open access

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Authors: Junjun Jing, Yang Chai, Tingwei Guo, Thach‐Vu Ho, Jifan Feng, Mingyi Zhang, Angelita Araujo-Villalba, Heliya Ziaei, Lin Meng
DOI: 10.25550/a2-0aar
Cited by: 0

Abstract

The histone demethylase KDM6B, expressed in cranial neural crest-derived dental mesenchyme, acts as a key epigenetic regulator coordinating sensory innervation during tooth root development. Loss of KDM6B impairs trigeminal axon entry and branching into the dental pulp by reducing the expression of the BMP antagonist Bambi, leading to overactivation of BMP signaling and suppressed NGF expression, which hinders sensory axon extension.

Fields of Study & Subjects

dental development and anomalies Developmental Biology and Gene Regulation Neurogenesis and neuroplasticity mechanisms

Publication details

Journal / source
FaceBase Craniofacial Research Data Repository
Publication date
1 January 2026
Language
EN
Document type
Dataset