Exercise and Nutrition Stimuli for the Augmentation of Mitochondrial Quality Control in Skeletal Muscle

Exercise has a profound capacity to keep muscles health throughout life. It is increasingly recognised that benefits of regular exercise are underpinned by enhancing muscle cell function, particularly mitochondria – the part of the cell that produces energy. However, the molecular basis by which exercise improves mitochondrial quality and quantity remains poorly understood. This thesis uses a combination of animal and human models to investigate how factors such as sex and nutrition influence the molecular mitochondrial response to bouts of acute exercise. Improving understanding in this area may help guide future interventions and strategies to promote skeletal muscle health.