Microbiome from mice receiving FMT from sarcopenia patients

With the acceleration of the global aging process, healthy aging is a topic of substantial current interest. Sarcopenia is a progressive and generalized skeletal muscle disorder involving the accelerated loss of muscle mass and function, which is associated with the gut microbiome. To investigate the intervention between aging-related gut microbiome and sarcopenia, we conducted fecal microbiota transplantation (FMT) experiments on male germ-free (GF) mice, dividing them into three groups: those receiving transplants from healthy elderly individuals (HM group), those receiving from sarcopenia patients (SM group), and a subgroup of the SM group supplemented with probiotic BFS1243 (SML group). And then, those gut microbiomes and their metabolites, inflammatory factors, muscle mass, muscle functions, etc. were be detected.