Study on the mechanism of tumor influence on atherosclerosis by regulating amino acid metabolism

To investigate the effects of tumors on atherosclerosis and to demonstrate that alterations in amino acids or their downstream metabolites can influence atherosclerosis (AS) by influencing immune cell phenotypes, the researchers sought new anti-atherosclerosis therapeutic targets. Atherosclerotic aorta of mice with or without tumor was collected, single cells of aortic CD45+ were isolated, and single cell transcriptome sequencing was performed to explore the potential mechanism by which tumors may affect atherosclerosis.