Fulminant Fournier gangrene in bladder cancer: case report and review of the literature.

BACKGROUND: The introduction of new target therapies and immunotherapy combinations has dramatically improved the prognosis of cancer patients. Surgery and radiotherapy currently represent the cornerstones of loco-regional management, both for palliative and curative purposes. It is no coincidence, therefore, that in recent years the frequency of complications once considered rare has increased. CASE REPORT: Here we present the case of a patient affected by metastatic bladder cancer whose treatments (surgery, radiotherapy, and targeted therapy) favored a rapid and acute onset of Fournier syndrome. The fulminant course prevented the establishment of a potentially effective treatment. CONCLUSIONS: Fournier gangrene is an acute perineal necrosis caused by anaerobic bacteria. Management is complex and requires a quick multidisciplinary approach, even though, among cancer patients, mortality is very high.