Aqueous FeCl3-Mediated Assembly of heterocyclic compounds containing both pyrazole scaffolds and tertiary alcohol ester moieties

A green synthetic approach was reported for constructing heterocyclic compounds containing both pyrazole scaffolds and tertiary alcohol ester moieties using FeCl3 catalysis in water. The method demonstrated broad substrate scope, high functional group tolerance and easy operation, achieving yields of 35-86%. The protocol’s efficiency in aqueous conditions highlights its environmental advantages while maintaining synthetic versatility for bioactive heterocycles. Furthermore, the amplification experiment and synthetic transformations of the adducts including modifications of marketed drugs further highlighted their practicalities.