Nanoscale morphometric visualization of the endoplasmic reticulum under stress using a bright zinc complex

ChemRxiv 2026 Preprint Open access

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Authors: Abdul Salam, Goraksha T. Sapkal, Bodhidipra Mukherjee, Sakshi Chouhan, Richa Garg, Shilpa Chandra, Chayan Kanti Nandi
DOI: 10.26434/chemrxiv-2026-xz82l
Cited by: 0

Abstract

The endoplasmic reticulum (ER) undergoes dynamic morphological changes during cellular stress and disease, yet specific staining and nanoscale observation remain challenging. We report a highly bright, biocompatible, and nontoxic fluorescent Zn-complex for super-resolution imaging of the ER. Super-resolution radial fluctuation microscopy (SRRF) resolves the smallest tubular diameter of ER, 110 nm, and quantifies stress-induced morphological remodeling.

Fields of Study & Subjects

Advanced Fluorescence Microscopy Techniques Endoplasmic Reticulum Stress and Disease Cellular transport and secretion

Publication details

Journal / source
ChemRxiv
Publication date
7 January 2026
Document type
Preprint