Bicyclo[2.1.1]hexanes: Saturated Bioisosteres of meta-Benzene

ChemRxiv 2026 Preprint Open access

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Authors: Aleksandr Denisenko, Yelyzaveta Makovetska, Oleksandr Stashkevych, Volodymyr Kokhalskyi, Oleh V. Shablykin, Vitalina Levchenko, Pavel Garbuz, Yevhen Skalenko, Iryna V. Sadkova, Liana Dmytrovska, Petro Borysko, Pavel K. Mykhailiuk
DOI: 10.26434/chemrxiv.15001067/v1
Cited by: 1

Abstract

In 2019, we hypothesised that bicyclo[2.1.1]hexanes could mimic meta-benzenes in bioactive compounds. In this work, we have proven this hypothesis experimentally.

Fields of Study & Subjects

Radical Photochemical Reactions Plant biochemistry and biosynthesis Organic Chemistry Cycloaddition Reactions

Publication details

Journal / source
ChemRxiv
Publisher
American Chemical Society (ACS)
Publication date
19 March 2026
Document type
Preprint