Unique fluoroalkyl substituents: the case of fluoroisopropyl (-CFMe2) group

ChemRxiv 2026 Preprint Open access

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Authors: Vadym Sham, Sofia Fok, Alexandra Rushchak, Mykhailo Komashnia, Dmytro Lutfullin, Dmytro Kyslyi, Yelyzaveta Makovetska, Maksym Mitiuk, Andrii Dudnyk, Anton Pochepko, Yarema Galushchak, Vadym Konashuk
+11 more Oleh Stanko, Alexander V. Rudnichenko, Daniil Skrypnik, Anton Tiasko, Olena Osypenko, O. V. Yakymchuk, Justyna Adamczyk, Petro Borysko, Vladimir Kubyshkin, Iryna V. Sadkova, Pavel K. Mykhailiuk
DOI: 10.26434/chemrxiv.15001396/v1
Cited by: 1

Abstract

The CFMe2-substituent is a close analogue of the CF3-group. The CF3 for CFMe2 replacement in model compounds mostly does not affect key physicochemical properties: water solubility, lipophilicity, and metabolic stability. Analogous replacement in the anticancer drug Enasidenib, however, provides a biologically active analogue with improved solubility and reduced lipophilicity.

Fields of Study & Subjects

Fluorine in Organic Chemistry Organometallic Complex Synthesis and Catalysis Inorganic Fluorides and Related Compounds

Publication details

Journal / source
ChemRxiv
Publisher
American Chemical Society (ACS)
Publication date
30 March 2026
Document type
Preprint