A modular approach to functionalized azetidines. Preparation of a bioactive Ciprofloxacine analogue.

ChemRxiv 2026 Preprint Open access

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Authors: Yarema Galushchak, Yeva Shevchenko, Andrii Slobodianyk, Roman Kotsiubchyk, Tibor Soós, Svitlana Bondaruk, Galeb Al-Maali, Pavel K. Mykhailiuk
DOI: 10.26434/chemrxiv.15002028/v1
Cited by: 1

Abstract

In 1924, Bruylants reported a reaction between aminonitriles (from ketones) and organomagnesium compounds. During the past 100 years, all possible ketones have been successfully used in this reaction except for one – N-Boc azetidinone. Here we report why that is and how to solve that problem.

Fields of Study & Subjects

Synthesis of β-Lactam Compounds Synthesis and Catalytic Reactions Asymmetric Synthesis and Catalysis

Publication details

Journal / source
ChemRxiv
Publisher
American Chemical Society (ACS)
Publication date
15 April 2026
Document type
Preprint