Union of the in situ Generated ortho-Quinone Methides (o-QMs) with Azabicyclo[1.1.0]butanes (ABB) towards the Synthesis of Functionalized Azetidines
Abstract
We herein disclose the reaction of in situ generated ortho-quinone methides (o-QMs) with Azabicyclo[1.1.0]butanes (ABB). The reaction proceeded through an orthogonal Lewis acid activation of the precursor compounds to o-QMs in presence of ABB and serves as the key for the current development. The 1,1,1,3,3,3-Hexafluoro-2-propanol (HFIP) plays an important role as solvent in the reaction. Importantly, similar reaction of p-QMs with ABB could be promoted only in HFIP. This study highlights a new strategy for the formation of functionalized azetidines..
Fields of Study & Subjects
Synthesis and Catalytic Reactions
Synthesis of Indole Derivatives
Synthesis of β-Lactam Compounds
Publication details
- Journal / source
- ChemRxiv
- Publisher
- American Chemical Society (ACS)
- Publication date
- 3 May 2026
- Document type
- Preprint