Spiro-helicenoid Carbofluoresceins: A New Family of Biocompatible CPL-Active Emitters

ChemRxiv 2026 Preprint Open access

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Authors: Laura Erviti-Marticorena, Silvia Simón‐Fuente, Sandra Míguez‐Lago, José M. Paredes, M. Ribagorda, María Dolores Girón, Alba Millán, Juan M. Cuerva, D. Miguel
DOI: 10.26434/chemrxiv.15005088/v1
Cited by: 1

Abstract

Chiral fluorescent probes based on small organic molecules present a promising platform for advanced bioimaging applications. Herein, we have developed a helically chiral spiro-shape carbofluorescein with near-infrared emission (λem up to 613 nm). Configurationally stable enantiomers were separated and electronic circular dichroism (ECD) and circularly polarized luminescence (CPL) evaluated. Preliminary results showed cellular permeability and intracellular emission.

Fields of Study & Subjects

Synthesis and Properties of Aromatic Compounds Molecular Sensors and Ion Detection Luminescence and Fluorescent Materials

Publication details

Journal / source
ChemRxiv
Publisher
American Chemical Society (ACS)
Publication date
23 June 2026
Document type
Preprint