Analysis of Molecular classification of Carcinoma Breast by Immunohisto chemistry in a series of core biopsied tissue at a Tertiary Care Hospital

Background: Breast cancer is a heterogeneous disease with diverse biological behavior and clinical outcomes. Molecular classification through immunohistochemistry (IHC) serves as a vital tool for predicting prognosis and tailoring therapy. This study aimed to evaluate the distribution of molecular subtypes by immunohistochemistry (IHC) in core biopsy samples in a Bangladeshi cohort and their correlation with clinicopathological parameters. Methods: 124 invasive breast carcinoma patients who received core needle biopsy at a tertiary care institution (2023-2024) were included. IHC profiling of ER, PR, HER2, and Ki67 was performed, and the tumors were placed into Luminal A, Luminal B, HER2-enriched, and Triple-negative subtypes. Clinicopathological factors, including tumor grade, size, and nodal status, were also investigated. Statistical significance was assessed by chi-square tests (SPSS v26.0). Results: Among 124 patients (median age: 50.2 ± 11.3 years), 46.8% of them had tumors