Sandwich-type thorium-substituted phosphotungstate for the catalytic synthesis of aza-heterocycles
Abstract
A novel sandwich-type thorium-substituted phosphotungstate, [H2N(CH3)2]10[Th(PW11O39)2]·24H2O (ThP2W22) was successfully synthesized and characterized, which is constructed from two mono-lacunary Keggin-type [PW11O39]7- units bridged by an eight-coordinate Th4+ ion. ThP2W22 demonstrates exceptional catalytic activity as a Lewis acid catalyst in the synthesis of 2,3-dihydroquinazolinones via cyclization of 2-aminobenzamides with aldehydes. Various quinazolinones were synthesized in excellent yield (75%-92%) under mild and green reaction conditions. Control experiments confirm the synergistic role of Th4+ and the polyoxometalate framework in enhancing catalytic efficiency, highlighting thorium-containing polyoxometalate as a promising catalyst in heterocycle synthesis.
Fields of Study & Subjects
Polyoxometalates: Synthesis and Applications
Multicomponent Synthesis of Heterocycles
Quinazolinone synthesis and applications
Publication details
- Journal / source
- Polyoxometalates
- Publisher
- Tsinghua University Press
- Volume
- 5
- Issue
- 2
- Pages
- 9140121–9140121
- Publication date
- 5 February 2026
- Language
- EN