Engineering Retro-Proteins Highlights Immunoglobulin-Domain Scaffold Plasticity as a Framework for Therapeutic Discovery
Abstract
Amino acid sequences of native proteins are generally not palindromic. The protein molecule obtained as a result of reading the amino acid sequence backwards, i.e., a retro-protein, has the same amino acid composition and the same hydrophobicity profile as the native sequence, but may behave as a different molecule.
Fields of Study & Subjects
Protein Structure and Dynamics
Monoclonal and Polyclonal Antibodies Research
Chemical Synthesis and Analysis
Publication details
- Journal / source
- Biomedical Journal of Scientific & Technical Research
- Volume
- 64
- Issue
- 4
- Publication date
- 5 February 2026
- Language
- EN