Prognostic value of the nutritional inflammatory score in NSTEMI: A decade of follow-up

To evaluate the prognostic value of the Nutritional Inflammatory Score (NIS) and neutrophil-to-lymphocyte ratio (NLR) in predicting long-term major adverse cardiovascular events (MACE) and all-cause mortality in patients with non-ST segment elevation myocardial infarction (NSTEMI). This retrospective cohort study included 314 patients with NSTEMI who were admitted between 2013 and 2016. Baseline NIS (calculated as albumin/NLR) and NLR values were obtained from admission laboratory data. The primary outcome was MACE, defined as a composite of cardiovascular death, recurrent myocardial infarction, heart failure hospitalization, and repeat revascularization. The secondary outcome was all-cause mortality. Patients were followed for a mean of 99.7 ± 22.0 months. Cox regression analysis, receiver operating characteristic (ROC) curves, and Kaplan-Meier survival estimates were used to assess prognostic significance. Multivariate Cox regression showed that NIS was an independent predictor of both MACE (HR: 0.719, 95% CI: 0.631–0.819, p