SYNTHESIS, STRUCTURES AND UREASE INHIBITION STUDIES OF COPPER(II) AND ZINC(II) COMPLEXES DERIVED FROM N’-(4-BROMO-2-HYDROXYBENZYLIDENE)-4-HYDROXYBENZOHYDRAZIDE
Abstract
Two new copper(II) and zinc(II) complexes [Cu2(bhb)2(CH3OH)2] (1) and [Zn(Hbhb)2]·4CH3OH (2), where bhb and Hbhb are the dianionic and monoanionic forms of N’-(4-bromo-2-hydroxybenzylidene)-4-hydroxybenzohydrazide (H2bhb), respectively. The two complexes have been characterized by elemental analysis and physico-chemical method, as well as single crystal X-ray diffraction. The Cu atom in complex 1 is in square pyramidal coordination, and the Zn atom in complex 2 is in octahedral coordination. The compounds were tested for their urease inhibitory properties. The copper complex has strong activity (IC50 = 1.7 ± 0.3 μM).
Fields of Study & Subjects
Crystal structures of chemical compounds
Metal complexes synthesis and properties
Inorganic and Organometallic Chemistry
Publication details
- Journal / source
- Журнал структурной химии
- Volume
- 67
- Issue
- 5
- Pages
- 165430–165430
- Publication date
- 1 January 2026
- Language
- EN