Two cases of possible transmitted HIV drug resistance to all currently available integrase inhibitors, the Netherlands, 2025

Eurosurveillance 2026 Open access

Read full text
Authors: Jeroen J. A. van Kampen, Jolanda J C Voermans, Widia Soochit, Thibault Mésplède, Thijs Van De Laar, Wil A. van der Reijden, D M Burger, Noga Shalev, Ard van Sighem, Daniela Bezemer, Suzanne Jurriaans, Thomas van der Vaart
+2 more Hanna Katrien de Jong, Marc van der Valk
DOI: 10.2807/1560-7917.es.2026.31.8.2600108
Cited by: 1
References: 15

Abstract

Transmitted integrase inhibitor resistance in newly diagnosed HIV remains rare. We report two cases with baseline resistance to all currently available integrase inhibitors in the Netherlands in 2025. Clinical history and laboratory findings indicate possible transmitted resistance. The cases are not phylogenetically linked, representing two independent introductions of integrase inhibitor resistant HIV into the Dutch population. These observations highlight the need for strengthened surveillance and prevention efforts in Europe and globally.

Fields of Study & Subjects

HIV/AIDS drug development and treatment Pneumocystis jirovecii pneumonia detection and treatment Pharmaceutical Quality and Counterfeiting

Publication details

Journal / source
Eurosurveillance
Publisher
European Centre for Disease Control and Prevention (ECDC)
Volume
31
Issue
8
Publication date
26 February 2026
Language
EN