Association of the T1565C (rs5918) polymorphism of the ITGB3 gene with clinical characteristics, anatomical features and long-term adverse events in patients with chronic coronary artery disease after elective endovascular coronary interventions

Background . The T1565C (dbSNP ID: rs5918 ) polymorphism of the integrin gene ( ITGB3 ) is a risk factor for many diseases such as coronary heart disease (CHD), venous thrombosis, and oncology. The minor allele C is known to alter aspirin sensitivity and increase platelet aggregation, which may affect the incidence of cardiovascular complications after elective percutaneous coronary interventions (PCI). Aim : To study the association of the T1565C ( rs5918 ) polymorphism of the ITGB3 gene with clinical characteristics, anatomical features and long-term adverse events after elective PCI in patients with chronic CHD. Material and methods . The study included 364 patients with chronic CHD from a registry of elective PCI performed at the Research Institute of Cardiology of the Tomsk National Research Medical Center from 2010 to 2017. The association of polymorphic variants of rs5918 of the ITGB3 gene with long-term (5-year) adverse events was assessed using genotype frequency analysis and odds ratio (OR). Adverse events included death from cardiovascular and other causes, myocardial infarction (MI), stroke (CVA), and concomitant oncological diseases. Results . The genotype frequencies were: TT – 69.2%, TC – 28%, CC – 2.8%. The frequencies of T and C alleles were 83.2% and 16.8%. The presence of the T allele was associated with concomitant carbohydrate metabolism disorders in patients (OR = 1.502; CI [1.005–2.247]; S = 0.205; p = 0.047). The Charlson comorbidity index was higher in the group of carriers of the minor homozygous CC genotype compared to carriers of the T allele ( TC + TT groups) (Me ( Q1 – Q3 ); 4(3–5) vs 3(2–4), respectively, p = 0.025). No association was found between the rs5918 polymorphism of the ITGB3 gene and late adverse cardiovascular events and death from all causes. In the presence of the minor homozygous CC genotype, the chances of concomitant oncological diseases significantly increase (OR = 5.750; CI [1.359–24.335], S = 0.736, p = 0.035). Conclusion . The rs5918 polymorphism of the ITGB3 gene is associated with phenotype-specific characteristics of patients with chronic coronary artery disease who are eligible for elective PCI. These characteristics include varying degrees of comorbidity (as measured by the Charlson index), the frequency of carbohydrate metabolism disorders and cancer, as well as the severity and location of coronary lesions, which may impact the completeness of revascularization and the long-term prognosis of these patients.