Correlation of sperm DNA fragmentation index with routine semen parameters and its predictive value for clinical outcomes of in vitro fertilization
Abstract
Infertility refers to a couple's inability to conceive after a period of normal, unprotected sexual activity or to carry a pregnancy to full term. This study investigated the correlation between sperm DNA fragmentation index (DFI) and routine semen parameters, as well as its predictive value for in vitro fertilization (IVF) outcomes. A total of 158 infertile patients undergoing IVF-embryo transfer (ET) from September 2021 to February 2023 were enrolled. Based on DFI levels, patients were divided into a low-DFI group (DFI ≤ 25%, n=94) and a high-DFI group (DFI > 25%, n=64). Routine semen parameters were analyzed and correlated with DFI levels. DFI showed significant negative correlations with sperm motility, progressive motility (PR), and non-progressive motility (NP), and a positive correlation with immotility (IM) (P
Fields of Study & Subjects
Ovarian function and disorders
Sperm and Testicular Function
Reproductive Biology and Fertility
Publication details
- Journal / source
- African Journal of Reproductive Health
- Publisher
- African Journal of Reproductive Health (AJRH)
- Volume
- 30
- Issue
- 3
- Pages
- 95–103
- Publication date
- 17 February 2026
- Language
- EN