Prunella vulgaris L. Polysaccharide Alleviated Liver Injury in Carbon Tetrachloride-Induced Mice Via Regulating Oxidation Resistance, Inflammatory Response and Microbiota

Prunella vulgaris L. (P.vulgaris L.) is a traditional medicinal herb renowned for its various pharmacological properties through antioxidant and anti-inflammatory effects.The present study investigated the hepatoprotection of P. vulgaris L. polysaccharide against carbon tetrachloride-induced liver injury in mice.Thirty (n= 30) ICR mice were divided into a control group (AC), a CCl4-induced liver injury model (AM), and a P. vulgaris L. polysaccharide treatment group (AXK).The AM and AXK groups received intraperitoneal injections of 10% CCl4 every two days, while the AXK group was also intragastrically administered P. vulgaris L. polysaccharide @150 mg/kg/day.The present research indicated that CCl4 remarkably decreased liver weight (P