SIRT1 Inhibits Bovine Cartilage ECM Degradation and Apoptosis by Activating Nrf2/HO-1 and Inhibiting NF-κB Pathways
Abstract
This study explored the potential mechanism of SIRT1 in bovine osteoarthritis (OA).In vivo experiments evaluated the severity of damage to bovine tarsal cartilage tissue through pathological staining and Mankin scoring.When compared with healthy bovines, cartilage in OA-affected bovines displayed ECM degradation and increased Mankin scores (P
Fields of Study & Subjects
Osteoarthritis Treatment and Mechanisms
Sirtuins and Resveratrol in Medicine
Proteoglycans and glycosaminoglycans research
Publication details
- Journal / source
- Pakistan Veterinary Journal
- Publication date
- 9 March 2026
- Language
- EN